CALL FOR PAPERS Fetal Physiological Programming Maternal dietary iron restriction modulates hepatic lipid metabolism in the fetuses

نویسندگان

  • Junlong Zhang
  • Rohan M. Lewis
  • Chunli Wang
  • Nicholas Hales
  • Christopher D. Byrne
چکیده

Junlong Zhang, Rohan M. Lewis, Chunli Wang, Nicholas Hales, and Christopher D. Byrne Endocrinology and Metabolism Unit, Developmental Origins of Health and Disease (DOHaD) Division, School of Medicine, University of Southampton, Southampton General Hospital, and Centre for DOHaD, University of Southampton, Princess Anne Hospital, Southampton; and Department of Clinical Biochemistry, University of Cambridge, Addenbrookes Hospital, Cambridge, United Kingdom

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Maternal dietary iron restriction modulates hepatic lipid metabolism in the fetuses.

Maternal dietary Fe restriction reduced fasting plasma cholesterol and triglyceride (TG) concentrations in the fetuses, as well as decreased plasma TG levels in the adult offspring. To investigate how maternal Fe restriction was affecting fetal lipid metabolism, we investigated whether there were changes in liver lipid metabolism in the full-term fetuses. There was a approximately 27% (P < 0.05...

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BACKGROUND AND AIMS Moderately reduced maternal nutrient availability during pregnancy has adverse effects on the fetuses' growth and metabolism during and after pregnancy. The aim of this study was to explore effects of maternal nutrition restriction (MNR) on key metabolites of the fetal energy metabolism, particularly amino acids (AA), nonesterified fatty acids (NEFA), acylcarnitines and phos...

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Identifying a Window of Vulnerability during Fetal Development in a Maternal Iron Restriction Model

It is well acknowledged from observations in humans that iron deficiency during pregnancy can be associated with a number of developmental problems in the newborn and developing child. Due to the obvious limitations of human studies, the stage during gestation at which maternal iron deficiency causes an apparent impairment in the offspring remains elusive. In order to begin to understand the ti...

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تاریخ انتشار 2004